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7 signs you could benefit from hormone therapy

From hot flashes to hair loss, discover the telltale signals your body might be asking for hormonal support.

By Liz Krieger|Medically reviewed by Jamil Alkhaddo, M.D.
Last updated September 4, 2025

If you’re in your 40s or 50s, chances are that you know someone who can’t say enough good things about menopause hormone therapy (MHT), commonly known as hormone replacement therapy (HRT). Maybe they credit it with helping them sleep better, improving their mood, or just making them feel more like themselves again. Should you be on it too? Learn to spot the signs that you may need to talk to a doctor about MHT to supplement your body’s falling levels of estrogen and progesterone.

Hot flashes and night sweats

Hot flashes are those sudden, intense waves of heat that can leave you soaked in sweat, even in air-conditioned rooms. When they hit at night, they become night sweats, which can create a cascade of issues including sleep deprivation, fatigue, and cognitive difficulties. If getting a good night’s sleep has become elusive — perhaps you're regularly changing pajamas due to night sweats — or if hot flashes are interrupting your work or social life, this may be a sign that HRT might benefit you and you should talk to your doctor.

Sleep disturbances

Poor sleep quality can create a domino effect, leading to daytime fatigue, difficulty concentrating, and a worse mood. Hormone therapy isn’t right for all sleep issues, but if you've tried sleep hygiene improvements, meditation, and other non-hormonal solutions without success, and your sleep issues are may be linked to other menopausal symptoms (like hot flashes), MHT might be an option.

Find out more about sleep during menopause

Mood changes and irritability

The dramatic ups and downs of hormones can cause you to feel depressed, anxious, angry, or irritable more often. These emotional changes can strain relationships and make daily tasks more challenging. While MHT isn't FDA approved specifically for mood changes, it can be worth discussing with your doctor — especially if some of the mood problems are being brought on by sleeplessness from night sweats.

Vaginal dryness or discomfort

As estrogen levels drop, vaginal tissue becomes thinner, drier, and less elastic, which can lead to discomfort during sex, increased susceptibility to urinary tract infections, and general vaginal irritation. While systemic hormone therapy may be of some help, there are other options available, such as localized treatment delivered with a cream, tablet, or ring. "Low-dose vaginal estrogen therapy can be extremely helpful for minimizing those symptoms," says Dr. Monica Christmas, M.D., the associate medical director at The Menopause Society, and director of the Menopause Program and Center for Women’s Integrated Health at the University of Chicago.

Low sex drive

A decline in libido may be due to both physical factors, like pain during intercourse from vaginal dryness, fatigue, and lower testosterone impacting arousal, as well as psychological factors like stress, anxiety, and body image concerns. Local estrogen therapy applied to the vaginal area can help with the dryness and irritation while MHT with testosterone may help with low desire.

Learn more about libido and menopause

Urinary problems

As estrogen levels drop significantly during menopause, the urethral and vaginal tissues may become thinner, and could lead to increased frequency or urgency to pee, leaking when coughing or sneezing, and more UTIs. While hormone therapy is not a first-line treatment for urinary problems, if your doctor determines your bladder symptoms are primarily related to issues with your vulva, vagina, and bladder, local estrogen treatments — such as vaginal creams or rings — can help offer relief.

Hair loss

If your hair is becoming thinner, brittle, or falling out more than usual, alongside other menopausal symptoms, this could be another sign pointing toward hormone imbalance (estrogen can affect hair growth cycles). Though MHT may not be the first recommended treatment, there’s some evidence that hormonal therapy (or oral contraceptive pills) may be able to help with hair loss.

This content is for general educational and informational purposes. The content is not medical advice, does not diagnose any medical condition and is not a substitute for professional medical advice, diagnosis or treatment from a healthcare provider. Talk to your healthcare provider about any medical concerns.

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